![]() ![]() If we do not call this out, taking this season as both an opportunity and an invitation to ask for increasing diversity, it’ll die out. We are contending with erasure on all fronts. ![]() We take the sartorial temperature twice a year, and it is undeniable that we are steadily slipping backward when it comes to representation. The runway has always been the truest expression of where fashion exists. I was hopeful we would see continued progress, but there has been an unapologetic propensity toward thinness. Many people asked where I was and said the lack of diversity across all shows was felt. The response I got from stepping away for a season was interesting. It always claws on the back of my mind-Am I letting down the people who rely on me for representation, to feel seen and cared for? Candidly, I was also burned out and feeling the fatigue of the industry. I had been putting off doing this surgery for a couple of years because of the nature of my job: the pace of it, the pressure of supporting my team, and also the ramifications of saying no to an opportunity or a show from a messaging standpoint. It was a time when I was interrogating my own authority and autonomy of my own body, as well as the authority and autonomy over my time. The decision to take fall 2023 Fashion Week off came from the need to have a surgery that I had put off for a long time (which I go into in depth in my book Treasure, with photography by Zora Sicher). Below she shares why, now more than ever, she’s called to represent body diversity on the runway. Her absence was keenly felt in a season that lacked body diversity on the runways across New York, London, Paris, and Milan. Last season, however, Elsesser took a break from walking in any shows to have surgery. The renowned model has walked for the likes of Fendi, Versace, Simone Rocha, and Lanvin and has graced the cover of Vogue. In conclusion, EC-18 has a significant anti-tumor effect in this experimental model of biliary cancer suggesting potential for clinical application to this difficult cancer.Īnti-Tumor Effect Biliary Cancer EC-18 TLR-4.Since she was spotted on Instagram by Pat McGrath in 2015, Paloma Elsesser has become a fixture in the global fashion industry. ![]() TLR-4 mRNA and protein expression, measured by reverse transcriptase PCR (RT-PCR), real-time quantitative PCR and western blot analysis, showed suppression of TLR-4 expression in KIGB-5 cells treated with EC-18 compared with control. To investigate whether the anti-tumor effect of EC-18 is associated with suppression of tumor cell Toll-like receptor 4 (TLR-4) expression in addition to stimulation of the immune cells, KIGB-5 cells were exposed to LPS with or without EC-18. EC-18 treated groups showed only a few microscopic lung lesions and no evidence of metastatic lesion with highest dose whereas widespread gross lung lesions were observed in untreated control. At 4th, 8th, and 12th week the lungs were examined. Cancer (KIGB-5) cells were given intravenously to produce hematogenous metastatic lung lesions which were treated with EC-18 at 10, 25, and 50 mg/kg/day respectively. To study the effects of these cytokines stimulated by EC-18 on cancer cells, we applied hamster biliary cancer model, a difficult cancer to treat. EC-18 (monoacetyldiacylglyceride) stimulates T cell production of IL-2, IL-4, IL-12, IFN-gamma, and GM-CSF in vitro.
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